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A Brief Guide on Karyotyping

Karyotyping DNA Test

Karyotyping is a DNA test that examines a person’s chromosomes. Every human carries 23 pairs of chromosomes. If an individual has one or more chromosomes, it generates genetic abnormalities. Such abnormalities can cause many hereditary illnesses. Karyotyping is a way to identify such genetic diseases, birth abnormalities, and blood or lymph system problems.

Types of samples that you can use for this test are the following:

Although you can use almost any cell for tests, the ideal samples are:

  • Lymphocytes
  • Amniotic fluid
  • Blood sample
  • Bone marrow

Karyotyping Test

What is the procedure of this test?

  • First, we isolate the chromosomes from the nucleus of the cells, put them on a slide, and stain them.
  • Then we obtain a Microphotograph of the chromosomes.
  • Then we rearrange the chromosomal photos in a jigsaw puzzle form. After that, we match pairs and order them by size from highest to lowest numbers 1 to 22. And at last the 23rd pair of the sex chromosomes.
  • Then we orient the microphotographs of the chromosomes. Each chromosome resembles a striped straw. It has two arms of various lengths, a centromere, and a sequence of bright and dark horizontal bands.
  • The length of the arms and the placement of the bands help in determining top from bottom.
  • After completion of the chromosomal picture arrangement a professional checks the chromosome pairs and looks for irregularities.